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Strategies for the Design of Vitamin D Receptor Ligands
Tania R. Mutchie, Daniel A. Webb, Elliot S. Di Milo, Leggy A. Arnold
In: Badr M.Z. (eds) Nuclear Receptors. Springer, Cham, 2021, 199-217. |
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Biological evaluation and synthesis of calcitroic acid
Olivia B. Yu, Daniel A. Webb, Elliot S.Di Milo, Tania R. Mutchie, Kelly A. Teske, Taosheng Chen, Wenwei Lin, Carole Peluso-Iltis, Natacha Rochel, Moritz Helmstädter, Daniel Merk, Leggy A. Arnold*
Bioorganic Chemistry 2021, 116, 105310. |
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Synthesis and biological evaluation of calcioic acid
Olivia B. Yu, Tania R. Mutchie, Elliot S. Di Milo and Leggy A. Arnold*
Steroids 2019, 108536. |
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Alternative binding sites at the vitamin D receptor and their ligands
Tania R. Mutchie, Olivia B. Yu, Elliot S. Di Milo, and Leggy A. Arnold*
Molecular and Cellular Endocrinology 2019, 485, 1-8. |
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Novel VDR antagonists based on the GW0742 scaffold
Kelly A. Teske, Jonathan W. Bogart, Leggy A. Arnold*
Bioorganic & Medicinal Chemistry Letters 2018, 28, 351-354. |
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A parallel chemistry approach to identify novel nuclear receptor ligands based on the GW0742 scaffold
Kelly A. Teske, Ganesha Rai, Premchendar Nandhikonda, Preetpal Sidhu, Belaynesh D. Feleke, Anton Simeonov, Adam Yasgar, Ajit Jadhav, David J. Maloney, and Leggy A. Arnold*
ACS Combinatorial Chemistry 2017, 19, 646-656. |
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Calcitroic acid - a review
Olivia B. Yu and Leggy A. Arnold*
ACS Chemical Biology 2016, 11, 2665-2672. |
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Inhibitors for the Vitamin D Receptor–Coregulator Interaction
Kelly A. Teske, Olivia B. Yu and Leggy A. Arnold*
Vitamins and Hormones 2016, 100, 45-82. |
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Synthesis and Evaluation of Vitamin D Receptor-Mediated Activities of Cholesterol and Vitamin D Metabolites
Kelly A. Teske, Jonathon W. Bogart, Luis M. Sanchez, Olivia B. Yu, Joshua V. Preston, James M. Cook, Nicholas R. Silvaggi, Daniel D. Bikle, and Leggy A. Arnold*
European Journal of Medicinal Chemistry 2016, 109, 238-46. |
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Antitumor activity of 3-Indolylmethanamines 31B and PS121912
Margaret L Guthrie, Preetpal S. Sidhu, Emily K. Hill, Timothy C. Horan, Premchendar Nandhikonda, Kelly Teske, Nina Y. Yuan, Marino Sidorko, Revathi Kodali, James M. Cook, Lanlan Han, Nicholas R. Silvaggi, Daniel D. Bikle, Richard G. Moore, Rakesh K. Singh, and Leggy A. Arnold*
Anticancer Res. 2015, 35(11), 6001-6007. |
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Anticancer Activity of VDR-Coregulator Inhibitor PS121912
Preetpal S. Sidhu, Kelly Teske, Belaynesh Feleke, Nina Y. Yuan, Margaret L. Guthrie, Grant B. Fernstrum, Nishita D. Vyas, Lanlan Han, Joshua Preston, Jonathan W. Bogart, Nicholas R. Silvaggi, James M. Cook, Rakesh K. Singh, Daniel D. Bikle, Leggy A. Arnold*
Cancer Chemotherapy and Pharmacology 2014,74(4), 787-798.
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Identification of VDR antagonists among nuclear receptor ligands using virtual screening
Kelly Teske, Premchendar Nandhikonda, Jonathan W. Bogart, Belaynesh Feleke, Preetpal Sidhu, Nina Yuan, Joshua Preston, Robin Goy, Rakesh K. Singh, Daniel D. Bikle, James M. Cook, Leggy A. Arnold*
Nuclear Receptor Research 2014, 1, 1-5. |
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Modulation of Transcription mediated by the Vitamin D Receptor and the Peroxisome Proliferator-Activated Receptor δ in the presence of GW0742 analogs
Kelly Teske, Premchendar Nandhikonda, Jonathan W. Bogart, Belaynesh Feleke, Preetpal Sidhu, Nina Yuan, Joshua Preston, Robin Goy, Leggy A. Arnold*
J. Biomol. Res. Ther. 2014, 3, 111. |
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Vitamin D Receptor-Coactivator Binding Inhibitors
Preetpal S. Sidhu, Nicholas Nassif, Megan M. McCallum, Kelly Teske, Belaynesh Feleke, Nina Y. Yuan, Premchendar Nandhikonda, James M. Cook, Rakesh K. Singh, Daniel D. Bikle, Leggy A. Arnold*
ACS Med. Chem. Lett. 2014, 5(2), 199-204. |
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PT19c, Another Nonhypercalcemic Vitamin D2 Derivative, Demonstrates Antitumor Efficacy in Epithelial Ovarian and Endometrial Cancer Models
Nada Kawar, Shannon Maclaughlan, Timothy C. Horan, Alper Uzun, Thilo S. Lange, Kyu K. Kim, Russell Hopson, Ajay P. Singh, Preetpal S. Sidhu, Kyle A. Glass, Sunil Shaw, James F. Padbury, Nicholi Vorsa, Leggy A. Arnold, Richard G. Moore, Laurent Brard, Rakesh K. Singh*
Genes & Cancer 2013, 4(11-12), 524-534. |
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PPARδ agonist GW0742 interacts weakly with multiple nuclear receptors including the vitamin D receptor
Premchendar Nandhikonda^, Adam Yasgar^, Athena M. Baranowski, Preetpal S. Sidhu, Megan M. McCallum, Alan J. Pawlak, Kelly Teske, Belaynesh Feleke, Nina Y. Yuan, Chinedum Kevin, Daniel D. Bikle, Steven D. Ayers, Paul Webb, Ganesha Rai, Anton Simeonov, Ajit Jadhav, David Maloney, Leggy A. Arnold * Biochemistry 2013, 52, 4193-4203. |
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Discovery of the First Irreversible Small Molecule Inhibitors of the Interaction between the Vitamin D Receptor and Coactivators
Premchendar Nandhikonda, Wen Z. Lynt, Megan M. McCallum, Tahniyath Ara, Athena M. Baranowski, Nina Y. Yuan, Dana Pearson, Daniel D. Bikle, R. Kiplin Guy, Leggy A. Arnold*
J. Med. Chem. 2012, 55, 4640-51.
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Efficacy of a Non-Hypercalcemic Vitamin-D2 Derived Anti-Cancer Agent (MT19c) and Inhibition of Fatty Acid Synthesis in an Ovarian Cancer Xenograft Model
Richard G. Moore, Thilo S. Lange, Katina Robinson, Kyu K. Kim, Alper Uzun, Timothy C. Horan, Nada Kawar, Naohiro Yano, Sharon R. Chu, Quanfu Mao, Laurent Brard, Monique E. DePaepe, James F. Padbury, Leggy A. Arnold, Alexander Brodsky, Tun-Li Shen, Rakesh K. Singh*
PLOS one 2012, 7, e34443.
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Evaluation of the first Ergocalciferol-derived, non hypercalcemic anti-cancer agent MT19c in ovarian cancer SKOV-3 cell lines
Laurent Brard, Thilo S. Lange, Katina Robison, Kyu Kwang Kim, Tahniyath Ara, Megan Marie McCallum, Leggy A. Arnold, Richard G. Moore, Rakesh K. Singh*
Gynecologic Oncology, 2011, 123(2), 370-8
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Differential regulation of epidermal function by VDR coactivators
Daniel D. Bikle*, Arnaud Teichert, L.A. Arnold, Y. Uchid, P.M. Elias and Y. Oda
J Steroid Biochem Mol Biol. 2010, 121, 208-313.
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Quantification of the Vitamin D Receptor-Coregulator Interaction
Arnaud Teichert^, Leggy A. Arnold^, Steve Otieno, Yuko Oda, Indre Augustinaite, Timothy R. Geistlinger, Richard W. Kriwacki, R. Kiplin Guy, and Daniel D. Bikle*
Biochemistry 2009, 48, 1454-1461.
^first authors *corresponding author |
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